Dexone (dexamethasone)
Dexone is a medication that helps in the treatment of conditions that reduce the function of the adrenal glands. The generic name of Dexone is dexamethasone. It prevents the tissues from responding to swelling or inflammation. Dexone tablets are corticosteroids. This drug helps in altering the response of the body towards certain immune stimulation.
This medication is useful in treating inflammation, severe allergies and asthma and many eye and skin related conditions. It can even be prescribed for other conditions that are not mentioned in this medication guide.
Dosage
The dosage of Dexone (containing dexamethasone) can vary depending on the specific condition being treated, the severity of the symptoms, and individual factors. It is crucial to follow your healthcare provider's instructions or the directions on the prescription label. The typical dosage recommendations for Dexone are as follows:
For adults:
- Oral tablets: The initial dose usually ranges from 0.75 to 9 mg per day, divided into multiple doses.
- Intravenous (IV) or intramuscular (IM) injection: The dosage can range from 0.5 to 9 mg, administered every 4 to 12 hours, depending on the severity of the condition.
For children:
- The dosage for children will depend on their age, weight, and the specific condition being treated. It is determined by the healthcare provider and should be followed carefully.
It's important to note that these dosages are general guidelines, and individual dosing may vary. Your healthcare provider will determine the appropriate Dexone dosage for your specific needs. Always consult with them for accurate dosage instructions.
Composition
The key ingredient of dexone is dexamethasone. It is an adrenocortical steroid. It is a synthetic in nature. The inactive ingredients in the tablets are:
- Magnesium stearate
- Lactose monohydrate
- Starch
- Cosmetic ochre
- Sucrose
- FD&C Blue No. 1
- D&C Yellow No. 10
- FD&C Red No. 3
- FD&C Green No. 3
- FD&C Yellow No. 6
- FD&C Red No. 40
The inactive ingredients in the oral suspension are:
- Disodium edentate
- Propylene glycol
- Citric acid
- Glycerine
- Flavouring
- Propylene glycol
- Methylparaben
- Propylparaben
- Water
- Sorbitol
Uses
Dexone is used for the treatment of various conditions like hormone/blood/immune system disorders, arthritis, some eye and skin conditions, certain bowel disorders, breathing problems, allergic reactions and some types of cancers. It is even used as a test for a type of adrenal gland disorder (Cusing’s syndrome). This corticosteroid hormone decreases the body’s natural form of defensive response which further lessens allergic reactions and swellings.
Side-effects
There are many side-effects associated with the use of dexone which may require medical attention. Some of these are mentioned below:
- Agitation
- Aggression
- Blurred vision
- Anxiety
- Reduced amount of urine
- Dizziness
- Headache
- Slow, fast, irregular, or pounding heartbeat or pulse
- Irritability
- Mood changes
- Mental depression
- Nervousness
- Rattling and noisy breathing
- Tingling or numbness in the legs or arms
- Breathlessness
- Beating in the ears
- Trouble walking, thinking, or speaking
- Swelling of the hands, fingers, lower legs, or feet
- Troubled breathing when at rest
- Weight gain
- Backache
- Abdominal pain
- Abdominal burning or cramping
- Black, bloody, or tarry stools
- Darkening of the skin
- Hoarseness or cough
- Decreased vision
- Diarrhoea
- Eye pain
- Dry mouth
- Eye tearing
- Eye pain
- Growth of facial hair in females
- Fatigue
- Fainting
- Chills or fever
- Fractures
- Dry and flushed skin
- Fruit-like odour of the breath
- Indigestion or heartburn
- Loss of appetite
Contraindications
Under certain conditions, the patient should not be allowed to take dexone. They are:
- Allergic reaction to corticosteroids (glucocorticoids)
- Seizures
- High blood sugar
- Visible water retention
- Active tuberculosis
- Underactive thyroid
- Inactive tuberculosis
- Arginase Deficiency
- High cholesterol
- Exposure to Measles
- Exposure to Chickenpox
Dexone and pregnancy
FDA has assigned dexone to the Pregnancy Category C. Dexone is only recommended at the time of pregnancy when there aren’t any alternatives available and the benefits are greater than the risks.
Some frequently asked questions about Dexamethasone
What is dexamethasone?
Dexamethasone is a synthetic corticosteroid medication. It belongs to the glucocorticoid class of drugs and is commonly used to reduce inflammation and suppress the immune response in various medical conditions.
What conditions can dexamethasone treat?
Dexamethasone is used to treat a wide range of conditions, including inflammatory disorders, autoimmune diseases, allergic reactions, certain types of cancer, respiratory disorders, skin conditions, and hormonal imbalances. It can also be used as part of chemotherapy regimens.
How does dexamethasone work?
Dexamethasone works by binding to glucocorticoid receptors in the body, leading to a decrease in the production of certain chemicals involved in inflammation and immune response. By reducing inflammation and suppressing the immune system, it helps alleviate symptoms and manage various medical conditions.
Can dexamethasone be used to treat COVID-19?
Dexamethasone has shown effectiveness in reducing mortality rates in severely ill COVID-19 patients requiring respiratory support. It is used as a treatment option in hospitalized COVID-19 patients who require supplemental oxygen or mechanical ventilation. However, it is important to note that the use of dexamethasone for COVID-19 should be determined by healthcare professionals based on individual patient circumstances.
What are the common side effects of dexamethasone?
Common side effects of dexamethasone can include increased appetite, weight gain, fluid retention, mood changes, difficulty sleeping, increased blood sugar levels, gastrointestinal symptoms, and increased susceptibility to infections. Prolonged use or high doses may lead to more serious side effects. It is important to follow the prescribed dosage and discuss any concerns with your healthcare provider.
Can dexamethasone interact with other medications?
Dexamethasone may interact with certain medications, including other steroids, immunosuppressants, anticoagulants, antifungal medications, and some antibiotics. It is important to inform your healthcare provider about all the medications, supplements, or herbal products you are taking to avoid potential interactions.
Can dexamethasone be used during pregnancy or while breastfeeding?
Dexamethasone use during pregnancy or breastfeeding should be discussed with a healthcare provider. In some situations, the benefits may outweigh the potential risks, but individual circumstances and medical advice should be considered.
Can dexamethasone be stopped suddenly?
Abruptly stopping dexamethasone treatment can cause adrenal insufficiency, where the body's ability to produce cortisol is suppressed. It is important to follow the prescribed dosage and taper off the medication gradually as directed by your healthcare provider.
How should dexamethasone be taken?
Dexamethasone is available in various forms, including tablets, injections, and oral solutions. The specific instructions for taking dexamethasone will depend on the condition being treated. Always follow your healthcare provider's instructions or the directions on the prescription label.
Can dexamethasone cause allergic reactions?
While allergic reactions to dexamethasone are rare, it is possible to be allergic to the medication. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.
